USD/CZK is the exchange rate between the US dollar and the Czech koruna, showing how many koruna one dollar will buy. It is a minor-to-exotic pair that draws far less volume than the majors, so spreads are wide and the order book can be thin. Most retail traders meet the koruna through this dollar pair or its euro counterpart.
The dollar is the base currency and the koruna the quote currency, so a quote of 23.0000 means one dollar is worth 23.0000 koruna. When the price rises the dollar is gaining on the koruna; when it falls the koruna is gaining. You trade USD/CZK as a forex CFD rather than buying koruna outright: go long if you expect the dollar to gain, short if you expect it to ease. A pip falls on the fourth decimal place, and your result is simply the pips moved multiplied by your position size.
The koruna is steered domestically by the Czech National Bank, but its defining feature is how tightly it tracks the euro, given the Czech economy's close ties to the eurozone. In practice that means a lot of USD/CZK's day-to-day movement comes through the EUR/USD leg: when the dollar moves against the euro, the koruna usually follows. So watch CNB policy for the local story and EUR/USD for the bulk of the swing.
Say USD/CZK is trading at 23.0000 and you go long one standard lot (100,000 US dollars), expecting the dollar to strengthen. Each pip is worth 10 koruna, so a 50-pip rise to 23.0050 gives:
50 √ó 10 = 500 koruna (about $22)
A 50-pip fall to 22.9950 would instead cost 500 koruna. Your contract is worth $100,000, and at 30:1 leverage you post about $3,333 in margin, magnifying both gain and loss.